In preclinical as well as in clinical studies Ulrich Dirnagl’s research has revealed pathobiology which impacts on the outcome after a stroke. Several of these mechanisms can be therapeutically targeted, clinical trials are underway. In addition, through meta-research he was able to identify opportunities for improving research practice and to obtain evidence for the impact of interventions targeted to increase the value of biomedical research. At the Charité Universitätsmedizin Berlin Ulrich Dirnagl is Professor of Clinical Neuroscience and served as founding director of the Department of Experimental Neurology from 1999 until 2022. Since 2017 he is also the founding director of the QUEST Center for Responsible Biomedical Research at the Berlin Institute of Health. QUEST aims at overcoming the roadblocks in translational medicine by increasing the value and impact of biomedical research through maximizing the quality, reproducibility, generalizability, and validity of research