As a Vice President at Arnold Ventures, Stuart funded renowned work showing that scientific research is often irreproducible, including the Reproducibility Projects in Psychology and Cancer Biology. As a grantmaker, he helped launch the Center for Open Science, Vivli, the Meta-Research Innovation Center at Stanford, the Stanford Center for Reproducible Neuroscience, the Yale Collaboration on Research Integrity and Transparency, and the Evidence-Based Medicine DataLab at Oxford. He was instrumental in creating the TOP Guidelines, the world’s most widely-adopted standards for scientific publication. His grantmaking was featured in Wired, the Economist, the New York Times, and the Atlantic, among many others.